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It was described in by Lichtenstein and Jaffe who reported 15 cases. of pigmentation and endocrine dysfunction, with precocious puberty in females: report of five cases. New England Journal of Medicine, Boston, ,
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References pubertal gonadotropin secretion in girls with McCune–Albright syndrome. J. Clin disseminata, areas of pigmentation and endocrine dysfunction with precocious puberty in females.
N. Engl. J. Med. , – 2. Albright, F., Scoville, B., and Sulkowitch, H. W. (). Lichtenstein, L., and Jaffe, H. L. ().
Description:Specific antibodies have been found in LS. In , Friedrich defines LS as a dystrophic, not atrophic condition; "et atrophicus" dropped. To date though, very little evidence has been found to support this theory. Platelet rich plasma was reported to be effective in one study, producing large improvements in the patients' quality of life, with an average IGA improvement of 2. Pathophysiology[ edit ] Although it is not clear what causes LS, several theories have been postulated. The syndrome occurs chiefly in children and is not accompanied by systemic, metabolic, endocrine, or other skeletal changes.